No adverse effects were reported in single-agent overdose with pantoprazole in doses of 400 and 600 mg. Death following multi-agent ingestion was attributed to chloroquine and zopiclone rather than pantoprazole. Keep this leaflet. You may need to read it again. Blister pack: Store in the original package in order to protect from moisture.
Adequate and well-controlled studies in humans have not been done. No gender-related differences in the safety profile of intravenous pantoprazole were seen in international trials involving 166 men and 120 women with erosive esophagitis associated with GERD. In most patients, treatment of hypomagnesemia required magnesium replacement and discontinuation of the PPI.
Tablets may be taken before, during, or following the morning meal. Neither food nor antacids altered the bioavailability of pantoprazole. If your symptoms do not improve or if they become worse, check with your doctor. It is not known whether pantoprazole is distributed into human breast milk. The dosage of pantoprazole sodium for injection in patients with pathological hypersecretory conditions including Zollinger-Ellison Syndrome varies with individual patients. The recommended adult dosage is 80 mg intravenously every 12 hours. The frequency of dosing can be adjusted to individual patient needs based on acid output measurements.
It is recommended that pantoprazole, after reconstitution and admixture, be administered through a separate line, by itself, and without mixing with other intravenous fluids or medications. The in-line filter provided with the medication must be used to remove the precipitates that may form when the reconstituted solution is mixed with intravenous solutions. The CHMP noted that pantoprazole 20 mg was effective in the short-term treatment of reflux symptoms and that there is a long safety experience with the medicine as a prescription medicine. It was also of the opinion that, based on the experience of the use of pantoprazole, the availability of Pantozol Control without medical supervision is appropriate.
Acid secretion returns to normal levels without rebound hypersecretion within 1 week. Patients in whom intentional overdose is confirmed or suspected should be referred for psychiatric consultation. There was a 78% reduction in the C max and a 45% reduction in the AUC of MPA in patients receiving both pantoprazole and MMF. Adverse events seen in spontaneous reports of overdose generally reflect the known safety profile of pantoprazole. If you experience side effects like dizziness or disturbed vision, you should not drive or operate machines. ECL cell density was apparent after one year among 39 patients, the majority taking 40 to 80 mg pantoprazole for up to 5 years. ECL density appeared to plateau after 4 years. Dialysis removes insignificant amounts of pantoprazole. Use pantoprazole delayed-release tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures. In one study of gastric pH in healthy subjects, pantoprazole was administered orally 40 mg enteric coated tablets or intravenously 40 mg once daily for 5 days and pH was measured for 24 hours following the fifth dose. European Union EU called Pantozol. What is Pantozol Control used for? The active substance is pantoprazole. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.
Clopidogrel: Clopidogrel is metabolized to its active metabolite in part by CYP2C19. In a crossover clinical study, 66 healthy subjects were administered clopidogrel 300 mg loading dose followed by 75 mg per day alone and with pantoprazole 80 mg at the same time as clopidogrel for 5 days. On Day 5, the mean AUC of the active metabolite of clopidogrel was reduced by approximately 14% geometric mean ratio was 86%, with 90% CI of 79 to 93% when pantoprazole was coadministered with clopidogrel as compared to clopidogrel administered alone. Pharmacodynamic parameters were also measured and demonstrated that the change in inhibition of platelet aggregation induced by 5 µM ADP was correlated with the change in the exposure to clopidogrel active metabolite. In both studies, pantoprazole sodium for injection 160 or 240 mg per day in divided doses maintained basal acid secretion below target levels in all patients. Because pantoprazole has been shown to cause tumorigenic effects in animals, a decision should be made as to whether nursing should be discontinued or the medication withdrawn, taking into account the importance of pantoprazole to the mother. The following adverse reactions have been identified during postapproval use of pantoprazole sodium. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Always take this medicine exactly as your doctor or pharmacist has told you. Keep this medicine out of the sight and reach of children. Pantozol Control is a medicine that contains the active substance pantoprazole. It is available as gastroresistant tablets 20 mg. Protect from light. The reconstituted product should not be frozen. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Oral, 40 mg per day for up to four weeks. Do NOT change your dose, stop taking pantoprazole delayed-release tablets, or take pantoprazole delayed-release tablets for longer than prescribed without checking with your doctor. You should report any new and exceptional symptoms and circumstances whenever you see your doctor. As an aid to patient consultation, refer to Advice for the Patient, Pantoprazole Systemic. Pantoprazole sodium for injection may be administered intravenously through a dedicated line or through a Y-site. Significantly different from pantoprazole sodium for injection. These measures will help protect the environment. zoloft
The reconstituted solution may be stored for up to 2 hours at room temperature prior to further dilution. The admixed solution may be stored for up to 12 hours at room temperature prior to administration. An increased incidence of thyroid tumor in rats, although within the historical ranges for the strain tested, was observed following exposure to pantoprazole 200 mg per kg daily. Pantoprazole-induced liver enzyme induction results in increased metabolism of thyroid hormone, leading in turn to increased production of TSH, with subsequent increased trophic changes within the thyroid gland. No similar effects have been observed in humans following exposure to usual clinical doses. Patients should be instructed to inform their healthcare provider if they develop any unusual symptom, or if any known symptom persists or worsens. Due to its effects on gastric acid secretion, pantoprazole can reduce the absorption of drugs where gastric pH is an important determinant of their bioavailability. Like with other drugs that decrease the intragastric acidity, the absorption of drugs such as ketoconazole, ampicillin esters, atazanavir, iron salts, erlotinib, and mycophenolate mofetil MMF can decrease. Following oral or intravenous administration: 1 hour. If you have ever had a skin reaction after treatment with a medicine similar to Pantoprazole that reduces stomach acid. Pantoprazole delayed-release tablets may increase the risk of a serious form of diarrhea. Contact your doctor right away if stomach pain or cramps, severe or persistent diarrhea, or bloody or watery stools occur. Discuss any questions or concerns with your doctor. Do not use this medicine after the expiry date which is stated on the packaging after EXP. propecia order visa europe propecia
For a listing of dosage forms and brand names by country availability, see Dosage Forms sections. Caucasians and African-Americans and 17 to 23% of Asians. Long-term use of PPIs has also been associated with low levels of magnesium hypomagnesemia. If you have any questions about pantoprazole delayed-release tablets, please talk with your doctor, pharmacist, or other health care provider. Hurlbut KM Eds: POISINDEXR System. MICROMEDEX, Inc. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. All medicines may cause side effects, but many people have no, or minor, side effects. Pantozol Control is used for the short-term treatment of the symptoms of acid reflux in adults. Acid reflux is when acid produced in the stomach escapes into the gullet, causing heartburn and acid regurgitation acid flowing up into the mouth. GPT mammalian cell-forward gene mutation assay, the in vitro thymidine kinase mutation test with mouse lymphoma L5178Y cells, and the in vivo rat bone marrow cell chromosomal aberration assay. The symptoms of acute toxicity were hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor.
Canada JR ed: USP Dictionary of USAN and International Drug Names. The United States Pharmacopeial Convention, Inc. There was also no interaction with concomitantly administered antacids. Pantoprazole, by increasing gastric pH, has the potential to affect the bioavailability of any medication for which absorption is pH-dependent. Also, pantoprazole may prevent the degradation of acid-labile drugs. Long-term treatment eg, longer than 3 years with medicines like this one has rarely caused low vitamin B12 levels. Discuss any questions or concerns with your doctor. After first opening of the container, the product should be used within 3 months. ATPase results in a duration of antisecretory effect that persists longer than 24 hours for all doses tested 20 mg to 120 mg. Study 2 was a single-center, double-blind, parallel-group study to compare the clinical effects of pantoprazole sodium for injection and oral pantoprazole sodium. msis.info suprax
Oral, 20 mg once a day in the morning. Dose can be increased to 40 mg once a day in the morning in the case of recurrence. Oral, 40 mg per day for up to two weeks. Symptomatic response to therapy with pantoprazole does not preclude the presence of gastric malignancy. Compared to individual subject baseline prior to treatment with pantoprazole sodium for injection. Although serum half-life values increased to 7 to 9 hours and AUC values increased by 5- to 7-fold in hepatic-impaired patients, these increases were no greater than those observed in CYP2C19 poor metabolizers, where no dosage adjustment is warranted. These pharmacokinetic changes in hepatic-impaired patients result in minimal drug accumulation following once-daily, multiple-dose administration. No dosage adjustment is needed in patients with mild to severe hepatic impairment. Check with your doctor to see whether you should take a calcium and vitamin D supplement while you use pantoprazole delayed-release tablets. Best Time of Day to Nap? Rapidly absorbed. However, absorption may be delayed up to 2 hours or more if pantoprazole is taken with food. Sodium Chloride Injection, USP, or Lactated Ringer's Injection, USP. This study demonstrated that, after 10 days of repeated oral administration followed by 7 days of intravenous administration, the oral and intravenous dosage forms of pantoprazole sodium 40 mg are similar in their ability to suppress MAO and BAO in patients with GERD and a history of erosive esophagitis see Table 3. Also, patients on oral pantoprazole sodium who were switched to intravenous placebo experienced a significant increase in acid output within 48 hours of their last oral dose see Table 3. However, at 48 hours after their last oral dose, patients treated with pantoprazole sodium for injection had a significantly lower mean basal acid output see Table 3 than those treated with placebo. Black, 11 Hispanic, 44 White, 1 other with a history of erosive esophagitis were randomized to receive either 20 or 40 mg of oral pantoprazole once per day for 10 days period 1 and then were switched in period 2 to either daily intravenous pantoprazole or placebo for 7 days, matching their respective dose level from period 1. Patients were administered all test medication with a light meal. F96022 in healthy volunteers. The medicine can be obtained without a prescription. How is Pantozol Control used? Pantoprazole is extensively metabolized in the liver through the cytochrome P450 CYP system. Pantoprazole metabolism is independent of the route of administration intravenous or oral. The main metabolic pathway is demethylation, by CYP2C19, with subsequent sulfation; other metabolic pathways include oxidation by CYP3A4. There is no evidence that any of the pantoprazole metabolites have significant pharmacologic activity. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, hands, eyes, throat, or tongue; unusual hoarseness; bloody or watery stools; bone pain; chest pain; fast or irregular heartbeat; fever, chills, or sore throat; red, swollen, blistered, or peeling skin; severe or persistent diarrhea or stomach pain; severe or persistent nausea or vomiting; stomach cramps; symptoms of kidney problems eg, not able to pass urine, change in the amount of urine produced, blood in the urine, a big weight gain; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, nausea, loss of appetite, unusual tiredness; unexplained weight loss; unusual bruising or bleeding; vision changes. canadian pharmacy citalopram mastercard
Swallow pantoprazole delayed-release tablets whole. Do not break, crush, or chew before swallowing. Pantoprazole sodium for injection is supplied as a sterile, freeze-dried, white to off-white, porous cake or powder containing 40 mg of pantoprazole per vial. Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated. F. Protect from freezing and from light. Pantoprazole sodium USP is a white to off-white powder and is racemic. Pantoprazole has weakly basic and acidic properties.
Acute interstitial nephritis has been observed in patients taking PPIs including pantoprazole sodium for injection. ECL-cell proliferation and gastric neuroendocrine NE-cell tumors. Gastric NE-cell tumors in rats may result from chronic elevation of serum gastrin concentrations. The high density of ECL cells in the rat stomach makes this species highly susceptible to the proliferative effects of elevated gastrin concentrations produced by proton pump inhibitors. The most common side effects with Pantozol Control seen in around 1 patient in 100 are diarrhoea and headache. For the full list of all side effects reported with pantoprazole, see the package leaflet. What is Pantozol Control? Like all medicines, this medicine can cause side effects, although not everybody gets them. See USP Controlled Room Temperature. Pantoprazole delayed-release tablets may increase the risk of hip, wrist, and spine fractures in patients with weak bones osteoporosis. The risk may be greater if you use pantoprazole delayed-release tablets in high doses or for longer than a year, or if you are older than 50 years old. Contact your doctor if you have any questions about this information. By blocking the pumps, pantoprazole reduces acid production, relieving the symptoms of acid reflux. Due to extensive protein binding, pantoprazole is not readily dialyzable. Miller Stage II or III with at least 1 of 3 symptoms typical for reflux esophagitis acid eructation, heartburn, or pain on swallowing were randomized to receive either 40 mg intravenous pantoprazole or 40 mg oral pantoprazole daily for 5 days. After the initial 5 days, all patients were treated with 40 mg oral pantoprazole daily to complete a total of 8 weeks of treatment. Symptom relief was assessed by calculating the daily mean of the sums of the average scores for these 3 symptoms and the daily mean of the average score for each of the symptoms separately. There was no significant difference in symptom relief between pantoprazole sodium for injection and oral pantoprazole sodium therapy within the first 5 days. A repeat endoscopy after 8 weeks of treatment revealed that 20 out of 23 87% of the pantoprazole sodium for injection plus oral pantoprazole sodium patients and 19 out of 22 86% of the oral pantoprazole sodium patients had endoscopically proven healing of their esophageal lesions. Oral, 40 mg per day for up to eight weeks. An additional eight-week course may be considered in patients who have not healed after four to eight weeks of treatment. How Long Is an Ideal Nap? Pantoprazole. Remember to also mention any other ill-effects like pain in your joints. ramipril pills mail order online
Since pantoprazole is acid-labile, it is administered as an enteric-coated tablet to prevent gastric decomposition and to increase bioavailability. Tablets should be swallowed whole, and not split, chewed, or crushed. In the other study of 14 patients 38 to 67 years; 5 female; 2 Black, 12 White with Zollinger-Ellison Syndrome, treatment was switched from an oral proton pump inhibitor to pantoprazole sodium for injection. Pantoprazole sodium for injection maintained or improved control of gastric acid secretion. Limited human overdose data available with any proton pump inhibitors. CDAD. A diagnosis of CDAD should be considered for patients taking PPIs who develop diarrhea that does not improve. The FDA is working with manufacturers to include information about the increased risk of CDAD with use of PPIs in the drug labels. FDA is also reviewing the risk of CDAD in users of histamine H2 receptor blockers. Study 1 was a multicenter, double-blind, placebo-controlled, study of the pharmacodynamic effects of pantoprazole sodium for injection and oral pantoprazole sodium. Pantozol Control must not be used in people who are hypersensitive allergic to pantoprazole, soya or any of the other ingredients. Intravenous infusion, 40 mg at a rate of 3 mg 7 mL per minute over approximately fifteen minutes each day for seven to ten days. You may take antacids while you are using pantoprazole delayed-release tablets if you are directed to do so by your doctor. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to and during administration whenever solution and container permit. Pantoprazole peak serum concentration C max and area under the serum concentration-time curve AUC increase in a manner proportional to intravenous doses from 10 mg to 80 mg. Pantoprazole does not accumulate and its pharmacokinetics are unaltered with multiple daily dosing. Following the administration of pantoprazole sodium for injection, the serum concentration of pantoprazole declines biexponentially with a terminal elimination half-life of approximately one hour. The recommended dose of Pantozol Control is one tablet once a day until symptoms have stopped. The patient may need to take the medicine for two to three days in a row for symptoms to improve. If there is no improvement in symptoms within two weeks of continuous treatment, patients should consult their doctor. Patients should not take the medicine for longer than four weeks without consulting their doctor. Warfarin and phenprocoumon, which affect the thickening, or thinning of the blood. You may need further checks. Use pantoprazole delayed-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions. Some MEDICINES MAY INTERACT with pantoprazole delayed-release tablets. Hypomagnesemia, symptomatic and asymptomatic, has been reported rarely in patients treated with PPIs for at least three months, and in most cases after a year of therapy. These tablets are not recommended for use in children below 12 years. diflucan
The magnitude and time course for inhibition of pentagastrin-stimulated acid output PSAO by single doses 20 to 120 mg of pantoprazole sodium for injection were assessed in a single-dose, open-label, placebo-controlled, dose-response study. There are no adequate data from the use of pantoprazole in pregnant women. Excretion into human milk has been reported. In a clinical pharmacology study, pantoprazole 40 mg given orally once daily for 2 weeks had no effect on the levels of the following hormones: cortisol, testosterone, triiodothyronine T 3 thyroxine T 4 thyroid-stimulating hormone, thyronine-binding protein, parathyroid hormone, insulin, glucagon, renin, aldosterone, follicle-stimulating hormone, luteinizing hormone, prolactin and growth hormone. Atazanavir used to treat HIV-infection. Very high 98%; primarily to albumin. There have been postmarketing reports of increased INR and prothrombin time in patients receiving proton pump inhibitors, including pantoprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Patients treated with proton pump inhibitors and warfarin concomitantly should be monitored for increases in INR and prothrombin time. This may not be a complete list of all interactions that may occur. Ask your health care provider if pantoprazole delayed-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Some medical conditions may interact with pantoprazole delayed-release tablets. Store pantoprazole delayed-release tablets at room temperature, between 68 and 77 degrees F 20 and 25 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep pantoprazole delayed-release tablets out of the reach of children and away from pets. HGPRT forward mutation assay for mutagenic effects. Equivocal results were observed in the in vivo rat liver DNA covalent binding assay. Pantoprazole as a long-term treatment. Oral, triple therapy regimens of pantoprazole 40 mg, plus clarithromycin 500 mg, plus either amoxicillin 1000 mg or metronidazole 500 mg, in which all three medications are taken two times a day for seven days.
This medicine has been prescribed for you only. Do not pass it on to others. Published observational studies suggest that PPI therapy like pantoprazole sodium may be associated with an increased risk of Clostridium difficile associated diarrhea, especially in hospitalized patients. Ringer's injection before and after administration of pantoprazole. The reconstituted solution may be stored for up to 24 hours at room temperature prior to intravenous infusion and does not need to be protected from light. The total volume from both vials should be administered intravenously over a period of at least 2 minutes. If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. The reconstituted solution may be stored for up to 6 hours at room temperature prior to further dilution. The admixed solution may be stored at room temperature and must be used within 24 hours from the time of initial reconstitution. Both the reconstituted solution and the admixed solution do not need to be protected from light. cheap azelastine dosage
If you have severe liver problems. Please tell your doctor if you have ever had problems with your liver. The clinical significance of this finding is not clear. Hematologic: leukopenia reported in ex-U. Swallow tablets whole. Do not break, chew, or crush. See Usual adult dose. zithromax
habitat for humanity pantozol, purchase now pantozol shop, buy cheap pantozol next day delivery, purchase pantozol online australia, pantozol generic name, taking generic pantozol while pregnant, brand pantozol for sale, pantozol order over the counter, buy quality pantozol online, when pantozol in the us, price pantozol remedio, order now generic pantozol shop, buy pantozol online india, order pantozol mexico, order cheap pantozol shopping uk, pantozol buy one get one free, canada pantozol comp, pantozol purchase visa otc, pantozol cheap buy online shopping, cheap pantozol wikipedia, pantozol money order shop europe, price pantozol dose pack, cheapest pantozol purchase mastercard otc, generic pantozol perfect measure, cost pantozol cvs, order now pantozol store usa, pantozol online overnight delivery cod, money order now pantozol store, purchase pantozol high, can i purchase pantozol pills, buy online pantozol visa, does walmart canada sell pantozol, price pantozol fass, generic pantozol buy online uk, shop pantozol contraindicaciones, generic pantozol online low cost, pantozol buy online uk, pantozol shop online, generic pantozol user reviews, purchase generic pantozol shop otc, pantozol prices pharmacy, us tabs pantozol, cheap pantozol fass, buy pantozol canada walmart, online pantozol last, buy pantozol australia, pantozol pills order online pharmacy, pantozol price uae, cheapest pantozol order pharmacy usa, cheapest pantozol purchase store uk, can i buy pantozol in canada, comprar pantozol online no brasil, can i buy pantozol otc, price pantozol thailand, pantozol per pill, is buying pantozol online legal, purchase now cheapest pantozol payment, order pantozol tablets online, pantozol generic competition, cheap pantozol purchase shopping otc, buy pantozol iv, who has the pantozol, generic pantozol purchase online shop, pantozol shipping, pantozol best price uk, where can i purchase pantozol online, order generic pantozol by phone, pantozol buy online store usa, discounts for pantozol, store pantozol coupon, pantozol forte price, order now cheapest pantozol payment, purchase iv pantozol, purchase cheap pantozol store otc, order pantozol review, generic form of pantozol side effects, pantozol buy now visa australia, how to purchase pantozol usa, pantozol to purchase no rx, cheap pantozol generic, canadian pharmacy pantozol mastercard, pantozol pills mail order online, pantozol canada prices, cheap pantozol dosage, pantozol order visa europe
Pantoprazole is metabolized mainly by CYP2C19 and to minor extents by CYPs 3A4, 2D6 and 2C9. Pantoprazole sodium for injection is indicated for short-term treatment 7 to 10 days of adult patients with gastroesophageal reflux disease GERD and a history of erosive esophagitis. The data from these studies revealed that animals in both age groups respond to pantoprazole in a similar manner. Pantoprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and to heal. duloxetine canada prices
Acid secretion decreased by 100% after 2 hours of 80 mg intravenous administration. Caucasians and African-Americans and 17% to 23% of Asians are poor metabolizers. Do not take a double dose to make up for a forgotten dose. Take your next normal dose at the usual time. H-benzimidazole, a compound that inhibits gastric acid secretion. Its molecular formula is C 16H 14F 2N 3NaO 4S, with a molecular weight of 405. Cardiac monitoring and blood pressure evaluation with significant overdose. Monitor fluid status and electrolytes with prolonged vomiting.
Transition from oral to intravenous and from intravenous to oral formulations of gastric acid inhibitors should be performed in such a manner to ensure continuity of effect of suppression of acid secretion. Patients with Zollinger-Ellison Syndrome may be vulnerable to serious clinical complications of increased acid production even after a short period of loss of effective inhibition. Low blood magnesium levels have been reported rarely in patients taking PPIs for at least 3 months. In most cases, this effect was seen after a year of treatment. If you will be taking pantoprazole delayed-release tablets for a long time, or if you take certain other medicines eg, digoxin, diuretics your doctor may perform lab tests to check for low blood magnesium levels. Seek medical attention right away if you experience symptoms of low blood magnesium levels eg, dizziness; fast or irregular heartbeat; involuntary muscle movements; jitteriness or tremors; muscle aches, cramps, pain, spasms, or weakness; seizures.
This drug is only recommended for use during pregnancy when there are no alternatives and the benefit outweighs the risk. Comments: The effects in the nursing infant are unknown. No dose adjustment of clopidogrel is necessary when administered with an approved dose of pantoprazole sodium. Hepatic, extensive. The major enzyme involved in the metabolism of pantoprazole is the polymorphically expressed cytochrome P450 isoform S-mephenytoin hydroxylase, also known as CYP2C19. The primary metabolite is the conjugate desmethylpantoprazole. Some patients who are deficient in this enzyme system will be slow metabolizers of pantoprazole. Patients who are slow metabolizers 3% of Caucasians or African-Americans; 17% to 23% of Asians can produce plasma concentrations 5 times or more higher than patients with the enzyme present.